Experienced players can create all kinds of sounds, just with their right hand technique. About a year ago, I was playing at a blues jam, and during the break, a young player asked me, "How do you switch so fast from the bridge pickup to the neck pickup, sometimes in the middle of a fast phrase?" I told him, " I don't", and showed him my
guitar. He couldn't believe it, my
guitar had only one pickup - the neck pickup. I told him all about the hot and the sweet spots on a string.
Try for yourself -- take your guitar and switch to the neck pickup and set your amp on low volume. Pluck your string with a medium thick pick at a right angle with medium force. Start to pluck the string at the end of the fingerboard, and, slowly, go up towards the bridge. You will recognize a steady change in output and tone, and somewhere close to the center between bridge and neck, you will find that beautiful sweet spot. Now, change to a more forceful attack, and also change the angle of attack to 45 degrees; you'll be surprised of all the sounds you can get! Then, repeat the whole process with different pickup selections. Single coil pickups are generally more sensitive to these changes than large humbuckers. It requires a lot of practice before you can master this technique, but with practice, you can duplicate the effects of a wah wah pedal just by changing the force, the position and the angle of the attack.